Glucocorticoid Regulation of Plasma Ketone Body Concentration in Insulin Deficient Man
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Increase of urinary ketone body excretion in selenium-deficient rats is a ketone-specific change.
The effects of selenium (Se) deficiency on urinary ketone body excretion in starved rats were examined. Rats were fed a basal diet which was Se-deficient (Se content: 0.011 micrograms/g) or a Se-adequate diet (the basal diet supplemented with 0.1 micrograms Se/g as sodium selenite). On the 11th and 22nd week of the feeding period, Se-deficient status in rats fed the basal diet was verified by t...
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For years investigators have sought an assay for insulin which would combine virtually absolute specificity with a high degree of sensitivity, sufficiently exquisite for measurement of the minute insulin concentrations usually present in the circulation. Methods in use recently depend on the ability of insulin to exert an effect on the metabolism of glucose in vivo or in excised muscle or adipo...
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A double-isotope procedure was used to measure the effects of insulin and glucagon on ketone-body production and utilization (i.e. turnover) in the starved rat. Somatostatin was infused during the experiment to suppress the pancreatic release of either hormone. The immediate action of insulin in terms of ketone-body turnover that was most evident was a decreased production of 3-hydroxybutyrate,...
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Baile, C. A. (1969). Fedn Proc. Fedn Am. SOCS exp. Bwl. 28, 1306. Baile, C. A. & McLaughlin, C. L. (1970). J. Dairy Sci. 53, 1058. Baile, C. A. & Mayer, J. (1967). Am.J. Physiol. 213, 387. Baile, C. A. & Mayer, J. (196%). Am.J. Physiol. 214, 677. Baile, C. A. & Mayer, J. (19686). J. Dairy Sci. 51, 1490. Baile, C. A. & Mayer, J. (1969). Am.J. Physiol. 217, 1830. Baile, C. A. & Mayer, J. (1970). ...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1977
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem-44-6-1069